On a single device, you cannot utilise both pieces of software at the same time. This is due to the fact that both pieces of software may be resistant to each other. When running both Avast Cleanup and Malwarebytes at the same time, several users report that their antivirus software stops working after 5 or 10 minutes.
Furthermore, an internet connection difficulties may occur. When used together, they impact the performance of the system, the internet access speed, and both applications frequently stopped operating.